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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
8.48
Human Site:
T957
Identified Species:
12.44
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
T957
W
T
G
D
R
G
R
T
L
E
S
E
A
R
S
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
T957
W
T
G
D
R
G
R
T
L
G
S
E
A
R
S
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
I957
W
T
G
D
R
G
R
I
L
G
L
E
A
R
S
Dog
Lupus familis
XP_546656
989
110956
T945
W
P
R
G
R
G
R
T
Q
G
P
E
A
R
S
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
A959
W
P
G
G
R
G
K
A
Q
R
P
E
A
A
S
Rat
Rattus norvegicus
XP_002742497
1001
111922
A957
W
P
G
G
R
G
K
A
Q
R
P
E
A
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
Q998
G
F
G
G
R
G
Q
Q
R
G
P
R
G
R
S
Chicken
Gallus gallus
NP_001025807
1020
114626
E976
F
N
H
F
G
S
S
E
Y
S
R
E
L
G
S
Frog
Xenopus laevis
NP_001085699
1022
114003
G978
S
S
F
S
G
G
S
G
A
Q
R
N
S
G
K
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
G954
P
A
T
A
F
S
G
G
N
G
G
K
P
S
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
S1202
N
Q
G
A
S
S
T
S
W
G
S
A
N
R
N
Honey Bee
Apis mellifera
XP_394050
958
109977
K912
N
T
F
Q
E
N
S
K
K
R
F
K
K
D
R
Nematode Worm
Caenorhab. elegans
O61660
759
85420
C716
E
E
E
E
E
V
F
C
Q
C
P
E
P
M
R
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
P636
K
C
P
H
C
N
E
P
M
T
L
K
E
R
K
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
G867
R
R
G
G
R
G
R
G
V
Q
N
A
G
R
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
R883
G
Q
S
S
G
G
R
R
G
S
G
T
S
F
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
93.3
80
60
N.A.
46.6
46.6
N.A.
33.3
13.3
6.6
0
N.A.
20
6.6
6.6
6.6
P-Site Similarity:
100
93.3
80
60
N.A.
53.3
53.3
N.A.
40
20
26.6
6.6
N.A.
33.3
13.3
13.3
20
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
33.3
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
60
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
13
0
0
0
13
7
0
0
13
38
13
7
% A
% Cys:
0
7
0
0
7
0
0
7
0
7
0
0
0
0
0
% C
% Asp:
0
0
0
19
0
0
0
0
0
0
0
0
0
7
0
% D
% Glu:
7
7
7
7
13
0
7
7
0
7
0
50
7
0
0
% E
% Phe:
7
7
13
7
7
0
7
0
0
0
7
0
0
7
0
% F
% Gly:
13
0
50
32
19
63
7
19
7
38
13
0
13
13
7
% G
% His:
0
0
7
7
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% I
% Lys:
7
0
0
0
0
0
13
7
7
0
0
19
7
0
13
% K
% Leu:
0
0
0
0
0
0
0
0
19
0
13
0
7
0
0
% L
% Met:
0
0
0
0
0
0
0
0
7
0
0
0
0
7
0
% M
% Asn:
13
7
0
0
0
13
0
0
7
0
7
7
7
0
7
% N
% Pro:
7
19
7
0
0
0
0
7
0
0
32
0
13
0
0
% P
% Gln:
0
13
0
7
0
0
7
7
25
13
0
0
0
0
0
% Q
% Arg:
7
7
7
0
50
0
38
7
7
19
13
7
0
50
13
% R
% Ser:
7
7
7
13
7
19
19
7
0
13
19
0
13
7
50
% S
% Thr:
0
25
7
0
0
0
7
19
0
7
0
7
0
0
0
% T
% Val:
0
0
0
0
0
7
0
0
7
0
0
0
0
0
7
% V
% Trp:
38
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _